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FAK ligand-5

FAK ligand-5 is a FAK ligand. FAK ligand-5 can be coupled with a linker to synthesize BI-4464. FAK ligand-5 can be used as a target protein ligand for PROTAC development, specifically for designing PROTAC FAK degraders. FAK ligand-5 can be used in the synthesis of PROTAC FAK degrader 4 (HY-178467). FAK ligand-5 can be used in cancer research[1].

Product Specifications

CAS Number

1227948-58-4

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

FAK; Ligands for Target Protein for PROTAC

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(O)C1=CC=C(NC2=NC=C(C(F)(F)F)C(OC3=CC=CC(CC4)=C3C4=O)=N2)C(OC)=C1

Molecular Formula

C22H16F3N3O5

Molecular Weight

459.37

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Liu C, et al. Structure-guided design of a potent focal adhesion kinase (FAK) degrader via ternary complex modeling and molecular dynamics simulation. Bioorg Chem. 2025 Oct;165:109017.

Shipping Conditions

Room temperature

Scientific Category

Reference compound2

Clinical Information

No Development Reported

Frequently Asked Questions

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