(1S,9R) -Ac-Exatecan

(1S,9R) -Ac-Exatecan is an intermediate for the synthesis of Exatecan (HY-13631) . Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM) [1].

Product Specifications

UNSPSC

12352005

Target

Drug Intermediate

Related Pathways

Others

Field of Research

Cancer

Smiles

O=C1OCC(C(N2C(C3=NC4=CC(F)=C(C5=C4C([C@H](CC5)NC(C)=O)=C3C2)C)=C6)=O)=C6[C@@]1(CC)O

Molecular Formula

C26H24FN3O5

Molecular Weight

477.48

References & Citations

[1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.