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Exatecan Intermediate 1 (Standard)

Exatecan Intermediate 1 (Standard) is the analytical standard of Exatecan Intermediate 1. This product is intended for research and analytical applications. Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan. Exatecan is a DNA topoisomerase I inhibitor with anticancer effects[1][2][3].

Product Specifications

CAS Number

110351-94-5

UNSPSC

12352005

Target

ADC Payload; Topoisomerase

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

O=C1[C@](O)(CC)C(C=C23)=C(CO1)C(N3CCC2=O)=O

Molecular Formula

C13H13NO5

Molecular Weight

263.25

References & Citations

[1]Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13 (4) :950-973. |[2]Zhang Hongwei, et al. Intermediate for synthesizing camptothecin derivatives using exatecan mesylate and its preparation method and application. China, CN111470998. 2020-07-31. |[3]Conilh L, et al. Exatecan Antibody Drug Conjugates Based on a Hydrophilic Polysarcosine Drug-Linker Platform. Pharmaceuticals (Basel) . 2021 Mar 9;14 (3) :247.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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