Tetraethylene glycol monotosylate
Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Tetraethylene glycol monotosylate also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.
Product Specifications
CAS Number
[77544-60-6]
Product Name Alternative
Tos-PEG4
UNSPSC
12352203
Hazard Statement
H301, H314
Target
ADC Linker; PROTAC Linkers
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
97.92
Solubility
10 mM in DMSO
Smiles
OCCOCCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O
Molecular Formula
C15H24O7S
Molecular Weight
348.42
Precautions
H301, H314
References & Citations
[1]Park KD, et al. Useful tools for biomolecule isolation, detection, and identification: acylhydrazone-based cleavable linkers.Chem Biol. 2009 Jul 31;16 (7) :763-72.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; PEG Linkers
Available Sizes
Curated Selection
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