(–) -JJ-450
(-) -JJ-450 is a non-competitive antagonist targeting the androgen receptor (AR) . (-) -JJ-450 is more potent than (+) -JJ-450 (HY-403733B) in inhibiting androgen-induced AR activity, and the mechanism of AR inhibition by (+) -JJ-450 is different from that of Enzalutamide (MDV3100) (HY-70003), which may target the ligand binding domain (LBD) of AR. (-) -JJ-450 inhibits the transcriptional activity of wild-type AR and mutant ARF876L by inhibiting AR nuclear translocation and promoting nuclear degradation of unbound AR. (-) -JJ-450 can be used in the study of castration-resistant prostate cancer (CRPC) resistant to Enzalutamide[1].
Product Specifications
CAS Number
[1998094-23-7]
UNSPSC
12352005
Target
Androgen Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C([C@H]1C[C@H]1C2=CC=C(C=C2)F)N3CCN(CC3)C4=CC(Cl)=CC=C4C
Molecular Formula
C21H22ClFN2O
Molecular Weight
372.86
References & Citations
[1]Cole RN, et al. (+) -JJ-74-138 is a Novel Noncompetitive Androgen Receptor Antagonist. Mol Cancer Ther. 2022 Apr 1;21 (4) :483-492.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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