JH-XII-03-02

JH-XII-03-02 is a potent and selective LRRK2 PROTAC degrader. JH-XII-03-02 can be used for parkinson's Disease (PD) research[1].

Product Specifications

CAS Number

[2415900-86-4]

UNSPSC

12352005

Target

LRRK2; PROTACs

Type

Reference compound

Related Pathways

Autophagy; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jh-xii-03-02.html

Purity

99.41

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1(CC1)OC2=CC=C(C3=C2)NN=C3C4=NC=NC(N5CCN(C(CCOCCOCCOCCOCCNC6=C7C(C(N(C8C(NC(CC8)=O)=O)C7=O)=O)=CC=C6)=O)CC5)=C4

Molecular Formula

C43H51N9O10

Molecular Weight

853.92

References & Citations

[1]John M Hatcher, et al. Development of a highly potent and selective degrader of LRRK2. Bioorg Med Chem Lett. 2023 Oct 1;94:129449.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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