JH-XII-03-02
Product Specifications
UNSPSC Description
JH-XII-03-02 is a potent and selective LRRK2 PROTAC degrader. JH-XII-03-02 can be used for parkinson's Disease (PD) research[1].
Target Antigen
LRRK2; PROTACs
Type
Reference compound
Related Pathways
Autophagy;PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jh-xii-03-02.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1(CC1)OC2=CC=C(C3=C2)NN=C3C4=NC=NC(N5CCN(C(CCOCCOCCOCCOCCNC6=C7C(C(N(C8C(NC(CC8)=O)=O)C7=O)=O)=CC=C6)=O)CC5)=C4
Molecular Weight
853.92
References & Citations
[1]John M Hatcher, et al. Development of a highly potent and selective degrader of LRRK2. Bioorg Med Chem Lett. 2023 Oct 1;94:129449.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155150/JH-XII-03-02-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155150/JH-XII-03-02-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2415900-86-4
Available Sizes
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