JH-XII-03-02
JH-XII-03-02 is a potent and selective LRRK2 PROTAC degrader. JH-XII-03-02 can be used for parkinson's Disease (PD) research[1].
Product Specifications
CAS Number
[2415900-86-4]
UNSPSC
12352005
Target
LRRK2; PROTACs
Type
Reference compound
Related Pathways
Autophagy; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jh-xii-03-02.html
Purity
99.41
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1(CC1)OC2=CC=C(C3=C2)NN=C3C4=NC=NC(N5CCN(C(CCOCCOCCOCCOCCNC6=C7C(C(N(C8C(NC(CC8)=O)=O)C7=O)=O)=CC=C6)=O)CC5)=C4
Molecular Formula
C43H51N9O10
Molecular Weight
853.92
References & Citations
[1]John M Hatcher, et al. Development of a highly potent and selective degrader of LRRK2. Bioorg Med Chem Lett. 2023 Oct 1;94:129449.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS7099697 Inquire
Recombinant Arabidopsis thaliana Uncharacterized membrane protein At1g16860 (At1g16860), partial
Sign In for Pricing
View Details 252187-ML750 100 µL
STIP1 (Stress-Induced-Phosphoprotein 1, HOP, IEF-SSP-3521, P60, STI1, STI1L) (MaxLight 750) discontinued
Sign In for Pricing
View Details MR223851L3V 200 µL
Asic5 (NM_021370) Mouse Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details 