JH-XII-03-02

[2415900-86-4]

12352005

LRRK2; PROTACs

Reference compound

Autophagy; PROTAC

Cancer-Kinase/protease

Cancer

https://www.medchemexpress.com/jh-xii-03-02.html

99.41

DMSO : 100 mg/mL (ultrasonic)

CC1(CC1)OC2=CC=C(C3=C2)NN=C3C4=NC=NC(N5CCN(C(CCOCCOCCOCCOCCNC6=C7C(C(N(C8C(NC(CC8)=O)=O)C7=O)=O)=CC=C6)=O)CC5)=C4

C43H51N9O10

853.92

[1]John M Hatcher, et al. Development of a highly potent and selective degrader of LRRK2. Bioorg Med Chem Lett. 2023 Oct 1;94:129449.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

Reference compound1

No Development Reported