JH-XII-03-02
JH-XII-03-02 is a potent and selective LRRK2 PROTAC degrader. JH-XII-03-02 can be used for parkinson's Disease (PD) research[1].
Product Specifications
CAS Number
[2415900-86-4]
UNSPSC
12352005
Target
LRRK2; PROTACs
Type
Reference compound
Related Pathways
Autophagy; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jh-xii-03-02.html
Purity
99.41
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1(CC1)OC2=CC=C(C3=C2)NN=C3C4=NC=NC(N5CCN(C(CCOCCOCCOCCOCCNC6=C7C(C(N(C8C(NC(CC8)=O)=O)C7=O)=O)=CC=C6)=O)CC5)=C4
Molecular Formula
C43H51N9O10
Molecular Weight
853.92
References & Citations
[1]John M Hatcher, et al. Development of a highly potent and selective degrader of LRRK2. Bioorg Med Chem Lett. 2023 Oct 1;94:129449.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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