Synucleozid-2.0

Synucleozid-2.0 is a small-molecule inhibitor targeting the iron-responsive element (IRE) structure in the 5' untranslated region (5'UTR) of SNCA mRNA. Synucleozid-2.0 inhibits ribosome assembly onto SNCA mRNA and selectively reduces α-synuclein protein translation. Synucleozid-2.0 is promising for research of Parkinson's disease (PD) and related α-synucleinopathies[1].

Product Specifications

CAS Number

[613226-91-8]

UNSPSC

12352005

Target

DNA/RNA Synthesis; α-synuclein

Related Pathways

Cell Cycle/DNA Damage; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(NC1=CC2=C(C=C1)C=NN2)CSC3=NN=C(N3C4=CC=C(C=C4)Br)C5=CC=NC=C5

Molecular Formula

C22H16BrN7OS

Molecular Weight

506.38

References & Citations

[1]Tong Y, et al. Decreasing the intrinsically disordered protein α-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera. Proc Natl Acad Sci U S A. 2024 Jan 9;121 (2) :e2306682120.