α-Methyl-p-tyrosine (Standard)

α-Methyl-p-tyrosine (Standard) is the analytical standard of α-Methyl-p-tyrosine. This product is intended for research and analytical applications. α-Methyl-p-tyrosine is a competitive inhibitor of tyrosine hydroxylase, which converts tyrosine into DOPA. α-Methyl-p-tyrosine is also an orally active inhibitor of catecholamine synthesis, inhibiting the hydroxylation of tyrosine into DOPA. α-Methyl-p-tyrosine can be used in research related to epilepsy, glaucoma, cancer, and other related diseases[1][2][3][4].

Product Specifications

CAS Number

[658-48-0]

UNSPSC

12352100

Target

Reference Standards; Tyrosine Hydroxylase

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Neurological Disease

Smiles

O=C(C(C)(CC1=CC=C(C=C1)O)N)O

Molecular Formula

C10H13NO3

Molecular Weight

195.22

References & Citations

[1]R N Brogden, et al. alpha-Methyl-p-tyrosine: a review of its pharmacology and clinical use. Drugs. 1981 Feb;21 (2) :81-9.|[2]Abed WT. Differential effects of alpha-methyl-p-tyrosine and 6-hydroxydopamine on pentylenetetrazol seizures in mice. Pharmacol Biochem Behav. 1986 Nov;25 (5) :949-52.|[3]Drago F, et al. alpha-Methyl-p-tyrosine inhibits latanoprost-induced melanogenesis in vitro. Exp Eye Res. 1999 Jan;68 (1) :85-90.|[4]Jones NF, et al. Alpha-methyl-p-tyrosine in the management of phaeochromocytoma. Lancet. 1968 Nov 23;2 (7578) :1105-9.