Tubulin polymerization-IN-75

Tubulin polymerization-IN-75 (Compound 6) is an inhibitor for tubulin polymerization with an IC50 of 30 μM. Tubulin polymerization-IN-75 inhibits the proliferation of cancer cell Huh7 and 293T with IC50 of 14.3 μM and 13.8 μM[1].

Product Specifications

CAS Number

[5325-66-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Purity

98.0

Smiles

O=C(C1=CC=CC=C1)/C=C/C2=NC=CC=C2

Molecular Formula

C14H11NO

Molecular Weight

209.25

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Kim DY, et al., Design and biological evaluation of novel tubulin inhibitors as antimitotic agents using a pharmacophore binding model with tubulin. J Med Chem. 2006 Sep 21;49 (19) :5664-70.