ATIC-IN-2

ATIC-IN-2 (Compound 1) is a competitive inhibitor for the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), that binds to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM[1].

Product Specifications

CAS Number

[67095-44-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Concentration

10mM

Purity

98.0

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C1NS(=O)(NC2=C1NC=N2)=O

Molecular Formula

C4H4N4O3S

Molecular Weight

188.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Xu L, et al., Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. J Biol Chem. 2007 Apr 27;282 (17) :13033-46.