ATIC-IN-2
ATIC-IN-2 (Compound 1) is a competitive inhibitor for the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), that binds to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM[1].
Product Specifications
CAS Number
67095-44-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Concentration
10mM
Purity
98.0
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C1NS(=O)(NC2=C1NC=N2)=O
Molecular Formula
C4H4N4O3S
Molecular Weight
188.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Xu L, et al., Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. J Biol Chem. 2007 Apr 27;282 (17) :13033-46.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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