N-Formylkynurenine

N-Formylkynurenine is an intermediate in the catabolism of tryptophan. It is a formylated derivative of kynurenine. The formation of N-formylkynurenine is catalyzed by heme dioxygenases.

Product Specifications

CAS Number

[1022-31-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Purity

98.50

Solubility

DMSO : 2.5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=CNC1=C(C(CC(C(O)=O)N)=O)C=CC=C1

Molecular Formula

C11H12N2O4

Molecular Weight

236.22

Precautions

H302, H315, H319

References & Citations

[1]Wang Y, Leung E, Tomek P. N-formylkynurenine but not kynurenine enters a nucleophile-scavenging branch of the immune-regulatory kynurenine pathway. Bioorg Chem. 2025 Mar;156:108219. |[2]Basran J, Efimov I, Chauhan N, Thackray SJ, Krupa JL, Eaton G, Griffith GA, Mowat CG, Handa S, Raven EL. The mechanism of formation of N-formylkynurenine by heme dioxygenases. J Am Chem Soc. 2011 Oct 12;133 (40) :16251-7.