Thalidomide-5-OH (Standard)

Thalidomide-5-OH (Standard) is the analytical standard of Thalidomide-5-OH. This product is intended for research and analytical applications. Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs[1].

Product Specifications

CAS Number

[64567-60-8]

UNSPSC

12352100

Target

Apoptosis; Autophagy; Ligands for E3 Ligase; Reference Standards

Related Pathways

Apoptosis; Autophagy; Others; PROTAC

Field of Research

Cancer

Smiles

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(O)=C3)=O

Molecular Formula

C13H10N2O5

Molecular Weight

274.23

References & Citations

[1]Megan G Marks, et al. Effects of Putative Hydroxylated Thalidomide Metabolites on Blood Vessel Density in the Chorioallantoic Membrane (CAM) Assay and on Tumor and Endothelial Cell Proliferation. Biol Pharm Bull. 2002 May;25 (5) :597-604.