Boc3Arg

Boc3Arg is the tert-butyl carbamate-protected arginine. Boc3Arg is an efficient tag to induce degradation through directly localizing the protein to the 20S proteasome[1][2].

Product Specifications

CAS Number

[108787-91-3]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Proteasome

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

97.0

Solubility

DMSO : ≥ 200 mg/mL

Smiles

O=C(O)[C@H](CCC/N=C(NC(OC(C)(C)C)=O)/NC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O

Molecular Formula

C21H38N4O8

Molecular Weight

474.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Sun H, et al. Identification of Boc2Lys-Linked Ethacrynic Acid and Its Analogues As Efficient Glutathione S-Transferase Degraders. ACS Med Chem Lett. 2024 Oct 14;15 (11) :1852-1859.|[2]Marcus J.C. Long, et al. Inhibitor Mediated Protein Degradation. Chemistry & Biology. 2021, 19 (5) : 629-637.