Boc3Arg
Boc3Arg is the tert-butyl carbamate-protected arginine. Boc3Arg is an efficient tag to induce degradation through directly localizing the protein to the 20S proteasome[1][2].
Product Specifications
CAS Number
[108787-91-3]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Proteasome
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
97.0
Solubility
DMSO : ≥ 200 mg/mL
Smiles
O=C(O)[C@H](CCC/N=C(NC(OC(C)(C)C)=O)/NC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O
Molecular Formula
C21H38N4O8
Molecular Weight
474.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Sun H, et al. Identification of Boc2Lys-Linked Ethacrynic Acid and Its Analogues As Efficient Glutathione S-Transferase Degraders. ACS Med Chem Lett. 2024 Oct 14;15 (11) :1852-1859.|[2]Marcus J.C. Long, et al. Inhibitor Mediated Protein Degradation. Chemistry & Biology. 2021, 19 (5) : 629-637.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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