7-Methyl-guanosine-5'-triphosphate (disodium)

7-Methyl-guanosine-5'-triphosphate (m7GTP) disodium is a guanosine 5'-phosphate. 7-Methyl-guanosine-5'-triphosphate disodium phosphorothioate analog is a potent cap-dependent translation inhibitor[1].

Product Specifications

CAS Number

[104809-18-9]

Product Name Alternative

M7GTP (disodium)

UNSPSC

12352005

Hazard Statement

H302

Target

Nucleoside Antimetabolite/Analog

Related Pathways

Cell Cycle/DNA Damage

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Solubility

10 mM in DMSO

Smiles

CN1C(C2=O)=C(N=C(N)N2)[N+]([C@@H]3O[C@H](COP(OP(OP(O)(O[Na])=O)(O[Na])=O)([O-])=O)[C@@H](O)[C@H]3O)=C1

Molecular Formula

C11H16N5Na2O14P3

Molecular Weight

581.17

Precautions

P264-P270-P330-P501

References & Citations

[1]Kowalska J, et al. Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation. Bioorg Med Chem Lett. 2009 Apr 1;19 (7) :1921-5.