TL8-506 (GMP)

TL8-506 (GMP) is TL8-506 (HY-20457) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TL8-506 is a specific TLR8 agonist with an EC50 of 30 nM. TL8-506 has immunomodulatory effects and can be used in the study of tuberculosis and cancer immunotherapy[1][2].

Product Specifications

CAS Number

[1268163-15-0]

UNSPSC

12352005

Target

Bacterial; Interleukin Related; Toll-like Receptor (TLR)

Related Pathways

Anti-infection; Immunology/Inflammation

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C(C1=CC2=CC=C(C3=CC=CC(C#N)=C3)C=C2N=C(N)C1)OCC

Molecular Formula

C20H17N3O2

Molecular Weight

331.37

References & Citations

[1]Jun Tang, et al. Toll-Like Receptor 8 Agonist Strengthens the Protective Efficacy of ESAT-6 Immunization to Mycobacterium tuberculosis Infection. Front Immunol. 2018 Jan 24;8:1972. |[2]He M, S, et al. Combinations of Toll-like receptor 8 agonist TL8-506 activate human tumor-derived dendritic cells. J Immunother Cancer. 2022 Jun;10 (6) :e004268.