4-[ (1E) -2-Nitroethenyl]benzoic acid

4-[ (1E) -2-Nitroethenyl]benzoic acid is an E3 ligase ligand. 4-[ (1E) -2-Nitroethenyl]benzoic acid can be used for synthesis of PROTAC BRD4 Degrader-38 (HY-175240) [1].

Product Specifications

CAS Number

[821797-33-5]

UNSPSC

12352005

Target

Ligands for E3 Ligase

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Others

Smiles

OC(C1=CC=C(C=C1)/C=C/[N+]([O-])=O)=O

Molecular Formula

C9H7NO4

Molecular Weight

193.16

References & Citations

[1]Ouyang X, et al. Proteome-Wide Ligand and Target Discovery by Using β-Nitrostyrene Electrophiles: Supporting Targeted Protein Degradation. Angew Chem Int Ed Engl. 2025 Aug 4;64 (32) :e202504813.