Tetramethylpyrazine nitrone

Tetramethylpyrazine nitrone is a nitrone derivative of tetramethylpyrazine. Tetramethylpyrazine nitrone is an active ingredient from Ligusticum wallichii Franchat. Tetramethylpyrazine nitrone is a potent scavenger of free radicals with neuroprotective activitys in both rat and monkey models of ischemis stroke. Tetramethylpyrazine nitrone can suppress over-expression of neuroinflammatory marker vimentin[1][2].

Product Specifications

CAS Number

[1083171-75-8]

Product Name Alternative

TBN

UNSPSC

12352005

Target

Drug Derivative

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

CC1=C(C)N=C(C)C(/C=[N+](C(C)(C)C)\[O-])=N1

Molecular Formula

C12H19N3O

Molecular Weight

221.30

References & Citations

[1]Zhou, X., et al., (2023) . Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer's disease mouse model and proteomics analysis. Frontiers in pharmacology, 14, 1082602. |[2]Zhang, Z., et al., (2016) . Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy. Scientific reports, 6, 37148.