ER ligand-8
ER ligand-8 is an ER (Estrogen Receptor/ERR) ligand that can be used to synthesize the PROTAC molecule ERD-1233 (HY-169367) [1].
Product Specifications
CAS Number
[2229713-97-5]
UNSPSC
12352005
Target
Estrogen Receptor/ERR; Ligands for Target Protein for PROTAC
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
O=S(OC1=CC=C([C@H]2[C@@H](C3=CC=CC=C3)CCC4=C2C=CC(OC(C)(C)C)=C4)C=C1)(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)=O
Molecular Formula
C30H27F9O4S
Molecular Weight
654.58
References & Citations
[1]Ranjan Kumar Acharyya, et al. Discovery of ERD-1233 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader for the Treatment of ER+ Human Breast Cancer. J Med Chem. 2024 Nov 14;67 (21) :19010-19037.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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