AR-102
AR-102 has inhibitory activity towards Staphylococcus aureus. AR-102 exhibits a competitive potent inhibition of the F98Y mutant DHFR (Ki = 0.22 nM) . AR-102 has been determined as ternary complex with NADPH in both wild-type S. aureus DHFR and the TMP-resistant F98Y mutant enzyme[1].
Product Specifications
CAS Number
955005-63-7
UNSPSC
12352211
Target
Bacterial; Dihydrofolate reductase (DHFR)
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
O[C@@H](C1=CC2=CC=CC=C2S1)CC[C@@H]3[C@H]([C@H](C[C@H]3O)O)CCCCCCC(OCC(CO)(CO)CO)=O
Molecular Formula
C28H42O8S
Molecular Weight
538.69
References & Citations
[1]Oefner, C., et al., (2009) . Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus. Acta crystallographica. Section D, Biological crystallography, 65 (Pt 8), 751–757.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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