VRX-480773

VRX-480773 is an efficient non-nucleoside reverse transcriptase inhibitor (NNRTI), used for HIV infection. VRX-480773 has high specificity for HIV-1, with an EC50 for wild-type HIV-1 being 0.14 nM. VRX-480773 does not inhibit HIV-2, HBV or HCV, and has no effect on human DNA polymerase α/β. VRX-480773 retains inhibitory activity against Efavirenz (HY-10572) resistant strains, with EC50s mostly [1].

Product Specifications

CAS Number

[878670-89-4]

UNSPSC

12352005

Target

HIV; Reverse Transcriptase

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

O=C(NC1=CC=C(S(=O)(N)=O)C=C1Cl)CSC2=NN=C(Br)N2C3=C4C=CC=CC4=C(C5CC5)C=C3

Molecular Formula

C23H19BrClN5O3S2

Molecular Weight

592.92

References & Citations

[1]Zhang Z, et al. A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother. 2007 Feb;51 (2) :429-37.