AVE-5997
AVE-5997 is a selective b>D3 antagonist. AVE-5997 antagonizes MK-801 (HY-15084B) -induced hyperactivity. AVE-5997 can be used in the research of schizophrenia[1].
Product Specifications
CAS Number
[452917-21-4]
UNSPSC
12352005
Target
Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(NCCCCN1CCN(C2=CSC3=CC(C(F)(F)F)=CC=C32)CC1)NC4=CC=C(C)C=C4
Molecular Formula
C25H29F3N4OS
Molecular Weight
490.58
References & Citations
[1]Zhang M, et al. Effect of dopamine D3 antagonists on PPI in DBA/2J mice or PPI deficit induced by neonatal ventral hippocampal lesions in rats. Neuropsychopharmacology. 2006 Jul;31 (7) :1382-92.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
D3 Receptor
Curated Selection
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