AVE-5997

AVE-5997 is a selective b>D3 antagonist. AVE-5997 antagonizes MK-801 (HY-15084B) -induced hyperactivity. AVE-5997 can be used in the research of schizophrenia[1].

Product Specifications

CAS Number

[452917-21-4]

UNSPSC

12352005

Target

Dopamine Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(NCCCCN1CCN(C2=CSC3=CC(C(F)(F)F)=CC=C32)CC1)NC4=CC=C(C)C=C4

Molecular Formula

C25H29F3N4OS

Molecular Weight

490.58

References & Citations

[1]Zhang M, et al. Effect of dopamine D3 antagonists on PPI in DBA/2J mice or PPI deficit induced by neonatal ventral hippocampal lesions in rats. Neuropsychopharmacology. 2006 Jul;31 (7) :1382-92.