ML278

ML278 is an efficient, low toxicity, and plasma stable SR-BI (IC50 = 6 nM) lipid uptake inhibitor. ML278 enhances HDL binding while inhibiting SR-BI mediated lipid uptake. ML278 can be used for research on metabolic conditions[1].

Product Specifications

CAS Number

[1604821-43-3]

UNSPSC

12352005

Target

Scavenger Receptor Class B type I (SR-BI)

Related Pathways

Immunology/Inflammation

Field of Research

Metabolic Disease

Smiles

O=C(NC1=NC(C2=CC3=C(N(C(COC)=O)CC3)C=C2)=CS1)C4=CC(OC)=CC(OC)=C4

Molecular Formula

C23H23N3O5S

Molecular Weight

453.51

References & Citations

[1]Dockendorff C, et al. Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI) -Mediated Lipid Transport. ACS Med Chem Lett. 2015 Feb 2;6 (4) :375-380.