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DDP-38003

DDP-38003 (Compound 15) is an orally active KDM1A/LSD1 inhibitor with an IC50 value of 84 nM. DDP-38003 exhibits anticancer activity against promyelocytic leukemia[1].

Product Specifications

CAS Number

1831167-97-5

UNSPSC

12352005

Target

Histone Demethylase

Related Pathways

Epigenetics

Field of Research

Cancer

Smiles

O=C(NC1=CC=C([C@@H]2C[C@H]2N)C=C1)C(C=C3)=CC=C3N4CCN(C)CC4

Molecular Formula

C21H26N4O

Molecular Weight

350.46

References & Citations

[1]Vianello P, et al. Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent. J Med Chem. 2016 Feb 25;59 (4) :1501-17.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

KDM1/LSD1

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