Gonyautoxin II
Gonyautoxin II is a paralytic shellfish poisoning toxin. Gonyautoxin II can block of the voltage-gated sodium channels at axonal level, impeding nerve impulse propagation. Gonyautoxin II has killing activity against mouse neuroblastoma cells. Gonyautoxin II can be used for the researches of cancer and neurological disease[1][2].
Product Specifications
CAS Number
60508-89-6
UNSPSC
12352005
Hazard Statement
H300-H310
Target
Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer; Neurological Disease
Smiles
OC1([C@]23[C@](N=C(N3)N)([H])[C@@H](N=C(N2C[C@H]1OS(=O)(O)=O)N)COC(N)=O)O
Molecular Formula
C10H17N7O8S
Molecular Weight
395.35
Precautions
P262-P264-P270-P280-P302+P352-P330-P361+P364-P405-P501
References & Citations
[1]Jellett JF, et al. Toxicological evaluation of saxitoxin, neosaxitoxin, gonyautoxin II, gonyautoxin II plus III and decarbamoylsaxitoxin with the mouse neuroblastoma cell bioassay. Toxicol In Vitro. 1995 Feb;9 (1) :57-65.|[2]Walker JR, et al. Divergent Synthesis of Natural Derivatives of (+) -Saxitoxin Including 11-Saxitoxinethanoic Acid. Angew Chem Int Ed Engl. 2019 Feb 4;58 (6) :1689-1693.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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