Gonyautoxin II

Gonyautoxin II is a paralytic shellfish poisoning toxin. Gonyautoxin II can block of the voltage-gated sodium channels at axonal level, impeding nerve impulse propagation. Gonyautoxin II has killing activity against mouse neuroblastoma cells. Gonyautoxin II can be used for the researches of cancer and neurological disease[1][2].

Product Specifications

CAS Number

[60508-89-6]

UNSPSC

12352005

Hazard Statement

H300-H310

Target

Sodium Channel

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cancer; Neurological Disease

Smiles

OC1([C@]23[C@](N=C(N3)N)([H])[C@@H](N=C(N2C[C@H]1OS(=O)(O)=O)N)COC(N)=O)O

Molecular Formula

C10H17N7O8S

Molecular Weight

395.35

Precautions

P262-P264-P270-P280-P302+P352-P330-P361+P364-P405-P501

References & Citations

[1]Jellett JF, et al. Toxicological evaluation of saxitoxin, neosaxitoxin, gonyautoxin II, gonyautoxin II plus III and decarbamoylsaxitoxin with the mouse neuroblastoma cell bioassay. Toxicol In Vitro. 1995 Feb;9 (1) :57-65.|[2]Walker JR, et al. Divergent Synthesis of Natural Derivatives of (+) -Saxitoxin Including 11-Saxitoxinethanoic Acid. Angew Chem Int Ed Engl. 2019 Feb 4;58 (6) :1689-1693.