NSC 15830 (hydrochloride)

NSC 15830 (S- (1,2-Dichlorovinyl) -L-cysteine) hydrochloride is a nephrotoxin and metabolite of trichloroethylene. NSC 15830 hydrochloride inhibits pathogen-stimulated TNF-α[1][2][3].

Product Specifications

CAS Number

[2508026-62-6]

Product Name Alternative

S- (1,2-Dichlorovinyl) -L-cysteine (hydrochloride)

UNSPSC

12352211

Target

Drug Metabolite; TNF Receptor

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

N[C@@H](CS/C(Cl)=C/Cl)C(O)=O.Cl

Molecular Formula

C5H8Cl3NO2S

Molecular Weight

252.55

References & Citations

[1]Boldenow E, et al. The trichloroethylene metabolite S- (1,2-dichlorovinyl) -l-cysteine but not trichloroacetate inhibits pathogen-stimulated TNF-α in human extraplacental membranes in vitro. Reprod Toxicol. 2015 Apr;52:1-6.|[2]Lash LH, et al. Multigenerational study of chemically induced cytotoxicity and proliferation in cultures of human proximal tubular cells. Int J Mol Sci. 2014 Nov 18;15 (11) :21348-65.|[3]Yoo HS, et al. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects. J Toxicol Environ Health A. 2015;78 (1) :32-49.