KW-2450 (tosylate)

KW-2450 tosylate is an orally active Aurora A and B kinases, IGF-1R, and IR tyrosine kinases inhibitor. KW-2450 tosylate induces Apoptosis. KW-2450 tosylate also exhibits anticancer activity against triple-negative breast cancer[1].

Product Specifications

CAS Number

[1360433-93-7]

UNSPSC

12352005

Target

Apoptosis; Aurora Kinase; IGF-1R

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

OCC(N(CC1)CCN1CC2=CC(NC(C3=C(C)C=CS3)=O)=C(/C=C/C4=NNC5=C4C=CC=C5)C=C2)=O.CC6=CC=C(S(=O)(O)=O)C=C6

Molecular Formula

C35H37N5O6S2

Molecular Weight

687.83

References & Citations

[1]Kai K, et al. Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases. Mol Cancer Ther. 2015 Dec;14 (12) :2687-99.