Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

SCH 58261 (Standard)

SCH 58261 (Standard) is the analytical standard of SCH 58261. This product is intended for research and analytical applications. SCH 58261 is a potent, selective and competitive antagonist of adenosine A2A receptor with an IC50 of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively[1][2][3].

Product Specifications

CAS Number

160098-96-4

UNSPSC

12352100

Target

Adenosine Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Others

Field of Research

Cancer

Smiles

NC1=NC(N(CCC2=CC=CC=C2)N=C3)=C3C4=NC(C5=CC=CO5)=NN14

Molecular Formula

C18H15N7O

Molecular Weight

345.36

References & Citations

[1]Zocchi C, et al. Binding of the radioligand [3H]-SCH 58261, a new non-xanthine A2A adenosine receptor antagonist, to rat striatal membranes. Br J Pharmacol. 1996 Apr;117 (7) :1381-6.|[2]Varani K, et al. Pharmacological and biochemical characterization of purified A2a adenosine receptors in human platelet membranes by [3H]-CGS 21680 binding. Br J Pharmacol. 1996 Apr;117 (8) :1693-701.|[3]Xi J, et al. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts. J Mol Cell Cardiol. 2009 Nov;47 (5) :684-90.|[4]Kuzumaki N, et al. Multiple analyses of G-protein coupled receptor (GPCR) expression in the development of gefitinib-resistance in transforming non-small-cell lung cancer. PLoS One. 2012;7 (10) :e44368.|[5]Mediavilla-Varela M, et al. Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth. Cancer Biol Ther. 2013 Sep;14 (9) :860-8.|[6]Wardas J, et al. SCH 58261, a selective adenosine A2A receptor antagonist, decreases the haloperidol-enhanced proenkephalin mRNA expression in the rat striatum. Brain Res. 2003 Jul 11;977 (2) :270-7.|[7]Wardas J, et al. SCH 58261, an A (2A) adenosine receptor antagonist, counteracts parkinsonian-like muscle rigidity in rats. Synapse. 2001 Aug;41 (2) :160-71.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Human C10orf90 activation kit by CRISPRa
GA114667 1 Kit

Human C10orf90 activation kit by CRISPRa

Sign In for Pricing
View Details
DYNLRB2 (NM_130897) Human Recombinant Protein
TP319143M 100 µg

DYNLRB2 (NM_130897) Human Recombinant Protein

Sign In for Pricing
View Details
Isovaleric anhydride
TRC-I917578-500MG 500 mg

Isovaleric anhydride

Sign In for Pricing
View Details
hHR23A Recombinant Rabbit Monoclonal Antibody [JE38-49]
HA722215 100 µL

hHR23A Recombinant Rabbit Monoclonal Antibody [JE38-49]

Sign In for Pricing
View Details
2-Fluoroanisole
TRC-F587670-25G 25 g

2-Fluoroanisole

Sign In for Pricing
View Details
CD10 (Membrane Metalloendopeptidase) (MME/1870), CF405S conjugate, 0.1mg/mL
BNC041870-500 1x 500 µL

CD10 (Membrane Metalloendopeptidase) (MME/1870), CF405S conjugate, 0.1mg/mL

Sign In for Pricing
View Details