ZM241385 (Standard)
ZM241385 (Standard) is the analytical standard of ZM241385. This product is intended for research and analytical applications. ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM[1][2][3].
Product Specifications
CAS Number
139180-30-6
UNSPSC
12352100
Target
Adenosine Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Others
Field of Research
Neurological Disease; Cancer
Smiles
OC1=CC=C(CCNC2=NC3=NC(C4=CC=CO4)=NN3C(N)=N2)C=C1
Molecular Formula
C16H15N7O2
Molecular Weight
337.34
References & Citations
[1]Wang Z, et al. Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drugcandidate ZM241385. PLoS One. 2010 Nov 8;5 (11) :e13883. doi: 10.1371/journal.pone.0013883.|[2]Linden J, et al. Characterization of human A (2B) adenosine receptors: radioligandbinding, western blotting, and coupling to G (q) in human embryonickidney 293 cells and HMC-1 mast cells. Mol Pharmacol. 1999 Oct;56 (4) :705-13.|[3]Poucher SM, et al. The in vitro pharmacology of ZM 241385, a potent, non-xanthine A2a selective adenosinereceptor antagonist. Br J Pharmacol. 1995 Jul;115 (6) :1096-102.|[4]Ludwig S, et al. Impact of combination immunochemotherapies on progression of 4NQO-induced murine oral squamous cell carcinoma. Cancer Immunol Immunother. 2019 Jul;68 (7) :1133-1141.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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