RORγt inhibitor 4

RORγt inhibitor 4 (Compound 9a) is an orally active and a CNS-penetrating RORγt inhibitor. RORγt inhibitor 4 improves experimental autoimmune encephalomyelitis[1].

Product Specifications

CAS Number

[1426803-07-7]

UNSPSC

12352005

Target

ROR

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=C(NC1=CC(Cl)=C(C2=CC=CC=C2OC(F)(F)F)C(Cl)=C1)CC3=CC=C(S(=O)(C)=O)C=C3

Molecular Formula

C22H16Cl2F3NO4S

Molecular Weight

518.33

References & Citations

[1]Wang Y, et al. Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors. ACS Med Chem Lett. 2015 May 26;6 (7) :787-92.