GW 796406
GW 796406 is a novel vascular peptidase inhibitor. GW 796406’s inhibitory activity against NEP (IC50 ≈ 1.1-2.5 nM) is about three times that of ACE (IC50 ≈ 1.6-4.7 nM) . GW 796406 can be used for research on cardiovascular conditions[1].
Product Specifications
CAS Number
581096-47-1
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE) ; Neprilysin
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
CC(C)[C@H](CS)C(N[C@H](C(O)=O)CC1=CC=C(N2C=CC=N2)C=C1)=O
Molecular Formula
C18H23N3O3S
Molecular Weight
361.46
References & Citations
[1]Sulpizio AC, et al. Mechanism of vasopeptidase inhibitor-induced plasma extravasation: comparison of omapatrilat and the novel neutral endopeptidase 24.11/angiotensin-converting enzyme inhibitor GW796406. J Pharmacol Exp Ther. 2005 Dec;315 (3) :1306-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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