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GW 796406

GW 796406 is a novel vascular peptidase inhibitor. GW 796406’s inhibitory activity against NEP (IC50 ≈ 1.1-2.5 nM) is about three times that of ACE (IC50 ≈ 1.6-4.7 nM) . GW 796406 can be used for research on cardiovascular conditions[1].

Product Specifications

CAS Number

581096-47-1

UNSPSC

12352005

Target

Angiotensin-converting Enzyme (ACE) ; Neprilysin

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Smiles

CC(C)[C@H](CS)C(N[C@H](C(O)=O)CC1=CC=C(N2C=CC=N2)C=C1)=O

Molecular Formula

C18H23N3O3S

Molecular Weight

361.46

References & Citations

[1]Sulpizio AC, et al. Mechanism of vasopeptidase inhibitor-induced plasma extravasation: comparison of omapatrilat and the novel neutral endopeptidase 24.11/angiotensin-converting enzyme inhibitor GW796406. J Pharmacol Exp Ther. 2005 Dec;315 (3) :1306-13.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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