RWJ-58643 (hydrochloride)

RWJ-58643 hydrochloride is a β-trypsin inhibitor that inhibits allergic inflammation. RWJ-58643 hydrochloride (100 mg) significantly reduces nasal allergy symptoms, eosinophil infiltration, and IL-5 levels at low doses. RWJ-58643 hydrochloride causes late eosinophilia and elevated IL-5 levels at high doses (300 mg and 600 mg) . RWJ-58643 hydrochloride modulates allergic reactions by inhibiting the release of β-trypsin from mast cells.

Product Specifications

CAS Number

[287182-52-9]

UNSPSC

12352005

Target

Ser/Thr Protease

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C([C@H]1N(C[C@@H](C1)O)C(C)=O)NC(CCCNC(N)=N)C(C2=NC3=CC=CC=C3S2)=O.Cl

Molecular Formula

C20H27ClN6O4S

Molecular Weight

482.98

References & Citations

[1]Erin EM, et al. Effects of a reversible beta-tryptase and trypsin inhibitor (RWJ-58643) on nasal allergic responses. Clin Exp Allergy. 2006 Apr;36 (4) :458-64.