Solabegron-d8

Solabegron-d8 (GW 427353-d8) is deuterium labeled Solabegron. Solabegron (GW 427353) is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM[1]. Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome[1].

Product Specifications

CAS Number

[1250988-09-0]

Product Name Alternative

GW 427353-d8

UNSPSC

12352101

Target

Adrenergic Receptor; Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Endocrinology

Smiles

O=C(O)C1=C(C(C2=C(C([2H])=C(C(NCCNC[C@H](O)C3=CC=CC(Cl)=C3)=C2[2H])[2H])[2H])=C(C([2H])=C1[2H])[2H])[2H]

Molecular Formula

C23H15D8ClN2O3

Molecular Weight

418.94

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Hicks A, et al. GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog. J Pharmacol Exp Ther. 2007 Oct;323 (1) :202-9.|[3]Andersson KE, et al. Selective β3-adrenoceptor agonists for the treatment of overactive bladder. J Urol. 2013 Oct;190 (4) :1173-80.