TKA-731
TKA-731 is an NK1 receptor antagonist. TKA-731 can reverse mechanical hyperalgesia. TKA-731 can be used for research on neuropathic pain[1].
Product Specifications
CAS Number
[210776-01-5]
UNSPSC
12352005
Target
Neurokinin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(N([C@H](C(N(C)CC1=CC=CC=C1)=O)CC2=CC=C(C=CC=C3)C3=C2)C)[C@H](CCC4)N4C5=NC(C6=CC=CC=C6N5)=O
Molecular Formula
C35H35N5O3
Molecular Weight
573.68
References & Citations
[1]Sindrup SH, et al. The NK1-receptor antagonist TKA731 in painful diabetic neuropathy: a randomised, controlled trial. Eur J Pain. 2006 Aug;10 (6) :567-71.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
NK1R
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