LA-419

LA-419 is an orally active nitric oxide (NO) donor. LA-419 can significantly reduce the amount of fecal worm eggs excreted, shorten the duration of egg excretion, and also decrease the number of larvae in the lungs and the number of parasitic females in the intestines in mice infected with S. venezuelensis. LA-419 can reduce the formation of atherosclerosis in apolipoprotein E-deficient mice. LA-419 can be used for the researches of infection and cardiovascular disease[1].

Product Specifications

CAS Number

[263754-93-4]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

NO Synthase

Related Pathways

Immunology/Inflammation

Field of Research

Infection; Cardiovascular Disease

Smiles

[H][C@]12[C@]([C@@H](SC(C)=O)CO2)([H])OC[C@H]1O[N+]([O-])=O

Molecular Formula

C8H11NO6S

Molecular Weight

249.24

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Ruano AL, et al. Treatment with nitric oxide donors diminishes hyperinfection by Strongyloides venezuelensis in mice treated with dexamethasone. Acta Trop. 2015 Dec;152:90-95.