Ro-65-2299
Ro-65-2299 is an orally active retiferol Vitamin D analogue and a potential VDR agonist (ED50 = 180 nM) . Ro-65-2299 can induce thickening of the epidermis and exhibits antipsoriatic effect in hairless mice (ED50 = 7.5 mg/kg) . Ro-65-2299 can be used for the researches of inflammation and immunology, such as psoriasis[1].
Product Specifications
CAS Number
241151-12-2
UNSPSC
12352211
Target
Drug Derivative; VD/VDR
Related Pathways
Others; Vitamin D Related/Nuclear Receptor
Field of Research
Inflammation/Immunology
Smiles
O[C@H]1C[C@H](O)C/C(C1)=C/C=C/CCCC(C)(C)C/C=C\C(C(F)(F)F)(O)C(F)(F)F
Molecular Formula
C21H30F6O3
Molecular Weight
444.45
References & Citations
[1]Bolla NR, et al. Retiferols-synthesis and biological activity of a conceptually novel class of vitamin D analogs. Expert Opin Ther Pat. 2014 Jun;24 (6) :633-46.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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