SML-8-73-1
SML-8-73-1 is a nucleotide-based KRASG12C inhibitor. SML-8-73-1 can be used for the study of non-small cell lung cancer (NSCLC) [1][2].
Product Specifications
CAS Number
1536470-92-4
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Field of Research
Cancer
Smiles
O=C1C(N=CN2[C@@H]3O[C@H](COP(OP(OCCNC(CCl)=O)(O)=O)(O)=O)[C@@H](O)[C@H]3O)=C2N=C(N)N1
Molecular Formula
C14H21ClN6O12P2
Molecular Weight
562.75
References & Citations
[1]Lim SM, et al. Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. Angew Chem Int Ed Engl. 2014 Jan 3;53 (1) :199-204.|[2]Huang L, Guo Z, Wang F, Fu L. KRAS mutation: from undruggable to druggable in cancer. Signal Transduct Target Ther. 2021 Nov 15;6 (1) :386.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Frequently Asked Questions
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