Triplatin tetranitrate

Triplatin tetranitrate is a novel trinuclear platinum complex. Triplatin tetranitrate blocks G2/M phase. Triplatin tetranitrate can covalently bind to the DNA bases. Triplatin tetranitrate exhibits significant antitumor effects against neuroblastoma[1][2].

Product Specifications

CAS Number

[172903-00-3]

UNSPSC

12352100

Target

DNA Alkylator/Crosslinker

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

N[Pt+2](NCCCCCCN[Pt+2](N)(N)[Cl-])(N)NCCCCCCN[Pt+2](N)(N)[Cl-].O=N([O-])=O.O=N([O-])=O.O=N([O-])=O.O=N([O-])=O

Molecular Formula

C12H40Cl2N14O12Pt3

Molecular Weight

1228.69

References & Citations

[1]Riccardi A, et al. In vitro and in vivo antitumor activity of the novel trinuclear platinum complex BBR 3464 in neuroblastoma. Cancer Chemother Pharmacol. 2001 Jun;47 (6) :498-504. |[2]Banerjee T, et al. Compacting effect of BBR3464, a new-generation trisplatinum anticancer agent, on DNA. Biochimie. 2010 Jul;92 (7) :846-51.