FK-788

FK-788 is a PGI (2) and IP agonist with a strong anti-aggregation effect, with an IC50 of 18 nM and a high binding affinity for the human recombinant IP receptor, with a Ki value of 20 nM[1][2].

Product Specifications

CAS Number

[227951-89-5]

UNSPSC

12352005

Target

Prostaglandin Receptor

Related Pathways

GPCR/G Protein

Field of Research

Others

Smiles

O=C(O)COC1=C2CC[C@](O)(COC(N(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC2=CC=C1

Molecular Formula

C26H25NO6

Molecular Weight

447.48

References & Citations

[1]Kouji Hattori, et al. Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: orally active prostacyclin mimetics. Part 3. Bioorg Med Chem Lett. 2005 Jun 15;15 (12) :3091-5.|[2]Fujiko Takamura, et al. Metabolism investigation leading to novel drug design 2: orally active prostacyclin mimetics. Part 5. Bioorg Med Chem Lett. 2006 Sep 1;16 (17) :4475-8.