KRH-594

KRH-594 is an orally active angiotensin AT1 receptor antagonist. KRH-594 ameliorates the progression of diabetic nephropathy and hyperlipidaemia. KRH-594 inhibits cardiac hypertrophy[1].

Product Specifications

CAS Number

[167006-13-5]

UNSPSC

12352005

Target

Angiotensin Receptor

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cardiovascular Disease; Metabolic Disease

Smiles

O=C(C1=C(C(/N=C2SC(CC)=NN\2CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3)=O)CCC1)O

Molecular Formula

C25H23N7O3S

Molecular Weight

501.56

References & Citations

[1]Inada Y, et al. KRH-594, a new angiotensin AT1 receptor antagonist, ameliorates nephropathy and hyperlipidaemia in diabetic spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 2000 Apr;27 (4) :270-6.