JTV-506

JTV-506 is a potent ATP-sensitive potassium channel opener. JTV-506 inhibits Histamine (HY-B1204) -induced contraction of tracheal smooth muscle by activation of KATP channels. JTV-506 attenuates pulmonary vascular tone through its direct action on vascular smooth muscle cells. JTV-506 can be used for pulmonary hypertension research[1][2].

Product Specifications

CAS Number

[170148-29-5]

UNSPSC

12352005

Target

Potassium Channel

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cardiovascular Disease

Smiles

N#CC1=CC=C2C([C@@H](NC(C=C3)=NN(C)C3=O)[C@H](O)C(COC)(COC)O2)=C1

Molecular Formula

C19H22N4O5

Molecular Weight

386.40

References & Citations

[1]Ando T, et al. Effects of JTV-506, a new K+ channel activator, on airway smooth muscle contraction and systemic blood pressure. Clin Exp Allergy. 1997 Jun;27 (6) :705-13.|[2]Tsutsumi Y, et al. JTV-506, a new K (ATP) channel opener, relaxes pulmonary artery isolated from monocrotaline-treated pulmonary hypertensive rats. J Anesth. 2004;18 (3) :210-5.