MX-68

MX-68 is an orally active antifolate agent. MX-68 can prolong the lifespan of MRL/lpr mice, delay the onset of proteinuria, and inhibit the elevation of serum blood urea nitrogen and cholesterol levels. MX-68 is also an anti-rheumatic agent, which exerts potent antiproliferative effects on rheumatoid arthritis-related cells and can inhibit arthritis in rats. MX-68 can be used in the research of autoimmune diseases such as autoimmune kidney disease and rheumatoid arthritis[1][2].

Product Specifications

CAS Number

[156579-02-1]

UNSPSC

12352005

Target

Antifolate

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Inflammation/Immunology

Smiles

O=C(O)[C@@H](NC(C1=CC=C2N(CC3=NC4=C(N)N=C(N)N=C4N=C3)CCSC2=C1)=O)CCCC(O)=O

Molecular Formula

C22H24N8O5S

Molecular Weight

512.54

References & Citations

[1]Maruyama N, et al. An improved process for the large-scale preparation of antirheumatic agent MX-68. Organic process research & development, 2004, 8 (6) : 883-888.|[2]Mihara M, et al. A novel antifolate, MX-68, inhibits the development of autoimmune disease in MRL/lpr mice. Int Arch Allergy Immunol. 1997 Aug;113 (4) :454-9.