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BM 170249

BM 170249 is a peroxisome proliferator, particularly in the perivenous region of the central acini in the liver. BM 170249 significantly reduces serum triglyceride and cholesterol levels in rats. BM 170249 strongly induces the activity of key enzymes in the peroxisome fatty acid β-oxidation system (such as acyl-CoA oxidase AOX, multifunctional enzyme PH, and thiolase PT), but leads to decreased activity of catalase and uricase in peroxisome components. BM 170249 could be used in lipid-lowering studies[1].

Product Specifications

CAS Number

153655-35-7

UNSPSC

12352211

Target

PPAR

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Cardiovascular Disease

Smiles

O=C(O)C(Cl)(Cl)CCCCCCCCCCC(Cl)(Cl)C(O)=O

Molecular Formula

C14H22Cl4O4

Molecular Weight

396.13

References & Citations

[1]Lindauer M, et al. Zonal heterogeneity of peroxisomal enzymes in rat liver: differential induction by three divergent hypolipidemic drugs. Hepatology. 1994 Aug;20 (2) :475-86.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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